Edotreotide























































Edotreotide

DOTATOC.png
Names

IUPAC name
2-[4-[2-[[(2R)-1-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-4-[[(2R,3R)-1,3-dihydroxybutan-2-yl]carbamoyl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

Identifiers

CAS Number

  • 204318-14-9 ☒N

3D model (JSmol)
  • Interactive image

ChemSpider

  • 139675 ☒N


PubChem CID
  • 158782

UNII

  • U194AS08HZ ☑Y




Properties

Chemical formula
C65H92N14O18S2

Molar mass
 1,421.65 g·mol−1
Pharmacology

License data


  • EU EMA: by INN

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).


☒N verify (what is ☑Y☒N ?)

Infobox references




90Y labelled edotreotide


Edotreotide (USAN, codenamed SMT487, also known as (DOTA0-Phe1-Tyr3)octreotide, or DOTATOC) is a substance which, when bound to various radionuclides, is used in the treatment and diagnosis of certain types of cancer.[1]


It has been the subject of a trial by the National Cancer Institute to determine its effects in young cancer patients (up to 25 years of age) for its ability to locate malignant cancer cells without harming normal cells. Specific cancers being included in the trial include neuroblastoma, childhood brain tumours and gastrointestinal cancer.[2]



See also



  • DOTA-TATE, a similar compound


References





  1. ^ Martindale, The Extra Pharmacopoeia, 30th ed, p1161.


  2. ^ Radiolabeled Octreotide in Treating Children With Advanced or Refractory Solid Tumors




  • Bushnell, D. L.; O'Dorisio, T. M.; O'Dorisio, M. S.; Menda, Y.; Hicks, R. J.; Van Cutsem, E.; Baulieu, J. -L.; Borson-Chazot, F.; Anthony, L.; Benson, A. B.; Oberg, K.; Grossman, A. B.; Connolly, M.; Bouterfa, H.; Li, Y.; Kacena, K. A.; Lafrance, N.; Pauwels, S. A. (2010). "90Y-Edotreotide for Metastatic Carcinoid Refractory to Octreotide". Journal of Clinical Oncology. 28 (10): 1652–1659. doi:10.1200/JCO.2009.22.8585. PMC 4872330. PMID 20194865..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}










-

Popular posts from this blog

Eastern Orthodox Church

Image
Not to be confused with Oriental Orthodoxy, Eastern Christianity, or Eastern Catholic Churches. "Eastern Orthodoxy", "Orthodox Church", "Orthodox Catholic Church", and "Orthodox Christian Church" redirect here. For other uses, see Orthodox (disambiguation). This article may be too long to read and navigate comfortably . The readable prose size is 132 kilobytes. Please consider splitting content into sub-articles, condensing it, or adding or removing subheadings. ( January 2018 ) Part of a series on the Eastern Orthodox Church Mosaic of Christ Pantocrator, Hagia Sophia Overview Structure Theology (History of theology) Liturgy Church history Holy Mysteries View of salvation View of Mary View of icons Background Crucifixion / Resurrection / Ascension of Jesus Christianity Christian Church Apostolic succession Four Marks of the Church Orthodoxy Organization Autocephaly Patriarchate ...
Read more

Zagreb

Image
This article is about the Croatian capital city. For other uses, see Zagreb (disambiguation). City in City of Zagreb, Croatia Zagreb City Grad Zagreb City of Zagreb Clockwise, from top: St. Mark's Square, Croatian State Archives, Zagreb Tram, Art Pavilion, Cibona & HOTO towers and Croatian National Theatre. Flag Coat of arms Zagreb Location of Zagreb in Croatia Show map of Croatia Zagreb Zagreb (Europe) Show map of Europe Coordinates: 45°49′N 15°59′E  /  45.817°N 15.983°E  / 45.817; 15.983 Coordinates: 45°49′N 15°59′E  /  45.817°N 15.983°E  / 45.817; 15.983 Country   Croatia County City of Zagreb RC diocese 1094 Free royal city 1242 Unified 1850 Subdivisions 17 city districts 218 local committees (70 settlements) Government  • Type Mayor-Council  • Mayor Milan Bandić (BM 365)  • City Assembly 51 members BM 365, ZL, NS-R (14) SDP, GLAS, HNS, HSS, NH-PS (13) ...
Read more

Understanding the information contained in the Deep Space Network XML data?

Image
up vote 1 down vote favorite NASA's Deep Space Network activity can be viewed conveniently at https://eyes.nasa.gov/dsn/dsn.html but if you would like data in a more raw XML form, it can be accessed as described in this answer Below is a small Python script that reads the XML into a list of dictionaries, and saves it to disk as a JSON. The dictionaries are organized at the higher level by dish, then by spacecraft per dish. Question: What are the most-likely meanings of all the data field contained in the Deep Space Network XML data? This is the example url from the other answer, used in the script below: https://eyes.nasa.gov/dsn/data/1365107113.xml def dictify(r,root=True): # https://stackoverflow.com/questions/2148119/how-to-convert-an-xml-string-to-a-dictionary-in-python/30923963#30923963 if root: ret...
Read more